CT Manifestations of Abdominal Langerhans’ Cell Histiocytosis in Children: a report of 4 cases

We presented the abdominal computed tomography (CT) findings of four cases of Langerhans’ cell histiocytosis (LCH) in children (age ranged from 11 month-old to 2 year-old, two boys and two girls), who clinically had either fever, skin rash, hepatosplenomegaly, persistent jaundice, elevated liver enzymes, or lymphadenopathy. CT showed variable findings, including: hepatomegaly, splenomegaly, liver cirrhosis, hypoattenuating or ring-enhancing, nodular lesions in the liver, hepatic periportal low-density lesions and paraaortic lymph node enlargement. We assumed that the radiologic appearances of hepatic lesions in LCH might correlate with the histopathological features of hepatic involvement in LCH. Our four cases probably represented the different phases or stages of hepatic involvement in LCH.